Evaluation of Efficacy of Coenzyme Q10 in Management of Gingivitis & Slight Periodontitis -a Clinical Study

Periodontal disease is an inflammatory disease process, resulting from the interaction of a bacterial attack and host inflammatory response. Arrays of molecules are considered to mediate the inflammatory response including free radicals and reactive oxygen species (ROS). Periodontal pathogens can induce ROS overproduction and thus may cause collagen and periodontal cell breakdown. When ROS are scavenged by antioxidants, there can be a reduction of collagen degradation. Ubiquinone (reduced form coenzyme Q10 ) serves as an endogenous antioxidant which increases the concentration of CoQ10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation. The aim of the study was to evaluate the efficacy of Coenzyme Q10 ( Perio Q TM) as adjunct to scaling and root planning, in management of gingivitis and slight periodontitis. 30 systemically healthy patients in a split mouth study design, where one half of the arches were test sites (treated with scaling and root planing + Perio Q TM gel) and the other half of the arches were the control site were treated with scaling and root planing only .Results were compared statistically using Students’s paired T test, at baseline and at 1st and 2nd week intervals. Various clinical parameters like periodontal probing depth and bleeding on probing were evaluated .Also Plaque and Gingival Index were evaluated .There was a statistically significant improvement in gingival index and reduction in probing depth in test sites seen at the end of 2 weeks period. Sites with bleeding on probing were reduced more in the test group than in control. Hence, coenzyme Q10 can be said to have a beneficial effect clinically on gingivitis and slight periodontitis when used as adjunct to scaling and root planning. Keyword: Periodontal disease, Slight periodontitis, Antioxidants, Coenzyme Q10, Ubiquinone, Bioenergizer,